Human papillomavirus-associated plantar epidermoid cysts: MR and US imaging appearance

Yoshinao Sato, Taiki Nozaki, Masaki Matsusako, Hikaru Eto, Mizuko Matsui, Naoyuki Ohtake, Koyu Suzuki, Jay Starkey, Yukihisa Saida

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Epidermoid cysts are epithelial cysts that present as slow-growing intradermal or subcutaneous lesions. While recent epidemiological studies have isolated human papillomavirus (HPV) from plantar epidermoid cysts, imaging findings in HPV-associated epidermoid cysts have not been previously reported. We describe imaging findings in two patients with HPV-associated plantar epidermoid cysts. Magnetic resonance (MR) imaging and ultrasonography (US) showed linear arrangement of several adjacent globular cysts. This appearance is hypothesized to result from HPV-associated eccrine duct metaplasia leading to cyst formation and later traumatic rupture leading to formation of multiple adjacent cystic components. It may be useful to suggest assessing the presence of HPV antigen in plantar lesions having these imaging findings.

Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalSkeletal Radiology
Issue number2
Publication statusPublished - 2014 Feb
Externally publishedYes


  • Epidermoid cyst
  • Epidermoid inclusion cyst
  • HPV-associated epidermoid cyst
  • Human papillomavirus
  • Traumatic epidermoid cyst

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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