Human Papillomavirus Test for Triage of Japanese Women with Low-Grade Squamous Intraepithelial Lesions

Takashi Iwata, Toshihiko Hasegawa, Kazunori Ochiai, Ken Takizawa, Satoshi Umezawa, Hiroyuki Kuramoto, Mineo Ohmura, Kaneyuki Kubushiro, Hiroharu Arai, Masaru Sakamoto, Teiichi Motoyama, Kayoko Watanabe, Daisuke Aoki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We evaluated high-risk human papillomavirus (HR-HPV) DNA testing for high-grade cervical intraepithelial neoplasia (CIN) lesions by cobas HPV test and diagnostic HPV16/18 genotyping in Japanese women with low-grade squamous intraepithelial lesions. Of 357 patients, HR-HPV positivity prevalence was 75.6%, and 21.3% had grade 2 or higher CIN lesions (CIN2+), with the highest prevalence at 30 to 34 years. Negative predictive values of HR-HPV for CIN2+ in our patients were 93.1% (any age) and 94.9% (40-50 years). Absolute risk for CIN2+ in HR-HPV positive and HPV16/18 positive individuals was 25.9 and 35.1, respectively. Relative risk for CIN2+ lesions was 5.1 for HPV16/18 positive versus HR-HPV negative, and 3.8 for HR-HPV positive versus HR-HPV negative women. Predictive values of CIN2+ positive were higher for HPV16/18 positive women (any age) than 12 other HPV positive-genotypes, and highest (50%) at 40-50 years. The HPV16/18 genotyping might prevent women (>40 years) at risk of high-grade CIN lesions from undergoing unnecessary colposcopy/overtreatment of nonprogressive lesions.

Original languageEnglish
Pages (from-to)1509-1515
Number of pages7
JournalReproductive Sciences
Issue number12
Publication statusPublished - 2015 Dec 1


  • cervical intraepithelial neoplasia
  • cobas HPV test
  • high-risk human papillomavirus
  • low-grade squamous intraepithelial lesions

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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