Human spermatozoal RNAs

Toshio Hamatani

Research output: Contribution to journalReview articlepeer-review

111 Citations (Scopus)


Objective: To provide a focused review of the scientific literature pertaining to spermatozoal RNA. Design: Review of the literature and appraisal of relevant articles. Setting: Not applicable. Patient(s): Infertile male. Intervention(s): None. Main Outcome Measure(s): Spermatozoal RNAs as potential epigenetic modifiers in early embryo development and as clinical markers of male infertility. Result(s): The nucleus of mature spermatozoa contains a complex population of mRNAs and miRNAs despite its transcriptionally inert state. Conclusion(s): A specific set of functional RNAs are delivered into oocytes during fertilization and are thought to contribute extragenomically to early embryonic development. Even if spermatozoal RNAs is merely residual, it still has the potential to greatly improve the investigative and diagnostic potential of male infertility.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalFertility and Sterility
Issue number2
Publication statusPublished - 2012 Feb
Externally publishedYes


  • RNA
  • Sperm
  • miRNA
  • microarray
  • paramutation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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