Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Yoshifumi Uwamino; Takashi Yokoyama; Yasunori Sato; Ayako Shibata; Toshinobu Kurafuji; Akiko Tanabe; Masayo Noguchi; Tomoko Arai; Akemi Ohno; Hiromitsu Yokota; Ho Namkoong; Tomoyasu Nishimura; Kenjiro Kosaki; Naoki Hasegawa; Masatoshi Wakui; Mitsuru Murata; Hiromichi Matsushita

doi:10.1016/j.vaccine.2023.01.049

Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Yoshifumi Uwamino
, Takashi Yokoyama
, Yasunori Sato
, Ayako Shibata
, Toshinobu Kurafuji
, Akiko Tanabe
, Masayo Noguchi
, Tomoko Arai
, Akemi Ohno
, Hiromitsu Yokota
, Ho Namkoong
, Tomoyasu Nishimura
, Kenjiro Kosaki
, Naoki Hasegawa
, Masatoshi Wakui
, Mitsuru Murata
, Hiromichi Matsushita

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

Original language	English
Pages (from-to)	1545-1549
Number of pages	5
Journal	Vaccine
Volume	41
Issue number	9
DOIs	https://doi.org/10.1016/j.vaccine.2023.01.049
Publication status	Published - 2023 Feb 24

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibody
BNT162b2
COVID-19 vaccine
Cellular immunity
Third dose

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2023.01.049

Cite this

Uwamino, Y., Yokoyama, T., Sato, Y., Shibata, A., Kurafuji, T., Tanabe, A., Noguchi, M., Arai, T., Ohno, A., Yokota, H., Namkoong, H., Nishimura, T., Kosaki, K., Hasegawa, N., Wakui, M., Murata, M., & Matsushita, H. (2023). Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine. Vaccine, 41(9), 1545-1549. https://doi.org/10.1016/j.vaccine.2023.01.049

Uwamino, Y, Yokoyama, T, Sato, Y, Shibata, A, Kurafuji, T, Tanabe, A, Noguchi, M, Arai, T, Ohno, A, Yokota, H, Namkoong, H, Nishimura, T , Kosaki, K, Hasegawa, N, Wakui, M, Murata, M & Matsushita, H 2023, 'Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine', Vaccine, vol. 41, no. 9, pp. 1545-1549. https://doi.org/10.1016/j.vaccine.2023.01.049

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abstract = "Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.",

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AU - Sato, Yasunori

AU - Shibata, Ayako

AU - Kurafuji, Toshinobu

AU - Tanabe, Akiko

AU - Noguchi, Masayo

AU - Arai, Tomoko

AU - Ohno, Akemi

AU - Yokota, Hiromitsu

AU - Namkoong, Ho

AU - Nishimura, Tomoyasu

AU - Kosaki, Kenjiro

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AU - Matsushita, Hiromichi

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AB - Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

KW - Antibody

KW - BNT162b2

KW - COVID-19 vaccine

KW - Cellular immunity

KW - Third dose

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Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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