Hydroarylative cyclization of enynes with aromatic ketones catalyzed by a low-valent iron-phosphine complex

Yoichi Kitazawa; Takuya Kochi; Fumitoshi Kakiuchi

doi:10.1016/j.tetlet.2024.155409

Hydroarylative cyclization of enynes with aromatic ketones catalyzed by a low-valent iron-phosphine complex

Yoichi Kitazawa, Takuya Kochi, Fumitoshi Kakiuchi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We report here an iron-catalyzed C[sbnd]H functionalization of aromatic ketones via cyclization of enynes. The reaction is applicable to a variety of aromatic ketones and enables regioselective introduction of a hydrogen atom and an aryl group at the alkyne moiety and the olefin moiety, respectively.

Original language	English
Article number	155409
Journal	Tetrahedron Letters
Volume	155
DOIs	https://doi.org/10.1016/j.tetlet.2024.155409
Publication status	Published - 2025 Jan 30

Keywords

Aromatic ketones
C-H bond cleavage
Cycloaddition
Enynes
Iron catalyst

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2024.155409

Cite this

@article{f8e7d998e43b458e8d7b9e2802f7e124,

title = "Hydroarylative cyclization of enynes with aromatic ketones catalyzed by a low-valent iron-phosphine complex",

abstract = "We report here an iron-catalyzed C[sbnd]H functionalization of aromatic ketones via cyclization of enynes. The reaction is applicable to a variety of aromatic ketones and enables regioselective introduction of a hydrogen atom and an aryl group at the alkyne moiety and the olefin moiety, respectively.",

keywords = "Aromatic ketones, C-H bond cleavage, Cycloaddition, Enynes, Iron catalyst",

author = "Yoichi Kitazawa and Takuya Kochi and Fumitoshi Kakiuchi",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2025",

month = jan,

day = "30",

doi = "10.1016/j.tetlet.2024.155409",

language = "English",

volume = "155",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Hydroarylative cyclization of enynes with aromatic ketones catalyzed by a low-valent iron-phosphine complex

AU - Kitazawa, Yoichi

AU - Kochi, Takuya

AU - Kakiuchi, Fumitoshi

PY - 2025/1/30

Y1 - 2025/1/30

N2 - We report here an iron-catalyzed C[sbnd]H functionalization of aromatic ketones via cyclization of enynes. The reaction is applicable to a variety of aromatic ketones and enables regioselective introduction of a hydrogen atom and an aryl group at the alkyne moiety and the olefin moiety, respectively.

AB - We report here an iron-catalyzed C[sbnd]H functionalization of aromatic ketones via cyclization of enynes. The reaction is applicable to a variety of aromatic ketones and enables regioselective introduction of a hydrogen atom and an aryl group at the alkyne moiety and the olefin moiety, respectively.

KW - Aromatic ketones

KW - C-H bond cleavage

KW - Cycloaddition

KW - Enynes

KW - Iron catalyst

UR - http://www.scopus.com/inward/record.url?scp=85211622269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85211622269&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2024.155409

DO - 10.1016/j.tetlet.2024.155409

M3 - Article

AN - SCOPUS:85211622269

SN - 0040-4039

VL - 155

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 155409

ER -

Hydroarylative cyclization of enynes with aromatic ketones catalyzed by a low-valent iron-phosphine complex

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this