Hydrogel fiber cultivation method for forming bacterial cellulose microspheres

Kazuhiko Higashi, Norihisa Miki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Forming microspheres or microbeads from nanofibrous materials has recently attracted research interest for their applications in various fields, because these structures greatly impact cellular behaviors and functions. However, conventional methods of preparing microspheres or microbeads have limitations, such as limited variety of material. Here, we propose a new fabrication process for forming a nanofibrous microsphere composed of bacterial cellulose (BC), which is synthesized through fermentation by specific bacteria. The process uses a hydrogel fiber containing spherical cavities. The bacteria encapsulated into the cavities produce BC, resulting in the formation of BC microspheres. Because of its simplicity, robustness, and cost-effectiveness, this process is promising for applications, such as in biochemical engineering and cell delivery systems.

Original languageEnglish
Article number36
Issue number1
Publication statusPublished - 2018 Jan 17


  • Droplet
  • Emulsion
  • Microbeads
  • Microbes
  • Microcarriers
  • Microfabrication
  • Microfluidics
  • Monodispersity

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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