Hyperglycemia decreases dehydroepiandrosterone in Japanese male with impaired glucose tolerance and low insulin response

Akira Yamauchi, Izumi Takei, Shinya Nakamoto, Norimi Ohashi, Yuko Kitamura, Mikiya Tokui, Satomi Nakano, Sumiyo Takayama, Akira Kasuga, Fuminori Katsukawa, Takao Saruta

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13 Citations (Scopus)


Recent studies indicate that experimentally induced hyperinsulinemia may reduce serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S). Serum DHEA and DHEA-S decrease in diabetic patients, but the mechanism by which hyperglycemia decreases DHEA and DHEA-S is unknown. In this study, we investigated the effect of hyperglycemia on DHEA and DHEA-S in impaired glucose tolerance (IGT) by means of the 75g-oral glucose tolerance test (OGTT). We selected 30 male IGT patients receiving diet therapy only, whose insulinogenic Index was under 0.3. Oral glucose challenge significantly reduced DHEA (P=0.001) and DHEA-S (P<0.05) at 60 and 120 min after OGTT. Setting the value of DHEA and DHEA-S at time zero as 100%, we calculated the DHEA and DHEA-S values at 60 and 120 min after OGTT as %DHEA(-S) 60 min and %DHEA(-S)120 min, respectively. DHEA and DHEA-S at time zero showed no correlation with BMI, HbA1C, the sum of insulin values (ΣIRI) or the area under the curve of plasma glucose (AUC). We found decreases in %DHEA 60 min (r=-0.411, P<0.05), %DHEA-S 60 min (r=-0.508, P<0.01) and %DHEA-S 120 min (r=-0.393, P<0.05) as AUC increased, but ΣIRI showed no correlation with %DHEA(-S) 60 min or %DHEA(-S)120 min. We conclude that the depression of DHEA and DHEA-S after OGTT is attributable to hyperglycemia in male Japanese IGT with low insulin response.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalEndocrine journal
Issue number3
Publication statusPublished - 1996 Jun


  • Dehydroepiandrosterone (DHEA)
  • Hyperglycemia
  • Hyperinsulinemia
  • Impaired glucose tolerance (IGT)
  • Oral glucose tolerance test (OGTT)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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