Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

Masahiro Nagao; Shuichi Kato; Hideaki Hayashi; Hidemi Misawa

doi:10.1007/s00401-003-0759-1

Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

Masahiro Nagao, Shuichi Kato, Hideaki Hayashi, Hidemi Misawa

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Acta Neuropathologica
Volume	106
Issue number	6
DOIs	https://doi.org/10.1007/s00401-003-0759-1
Publication status	Published - 2003 Dec
Externally published	Yes

Keywords

Anterior horn
Dendrite
Excitatory
Inhibitory
Regeneration

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/s00401-003-0759-1

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title = "Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients",

abstract = "Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.",

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author = "Masahiro Nagao and Shuichi Kato and Hideaki Hayashi and Hidemi Misawa",

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language = "English",

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T1 - Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

AU - Nagao, Masahiro

AU - Kato, Shuichi

AU - Hayashi, Hideaki

AU - Misawa, Hidemi

PY - 2003/12

Y1 - 2003/12

N2 - Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

AB - Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

KW - Anterior horn

KW - Dendrite

KW - Excitatory

KW - Inhibitory

KW - Regeneration

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ER -

Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

Abstract

Keywords

ASJC Scopus subject areas

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