@article{36671293e8ae47caa9215ef9dff1ddfb,
title = "Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm",
abstract = "The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue hypoxia has previously been observed as a manifestation of enlarged abdominal aortic aneurysms (AAAs). We sought to determine whether hypoperfusion of the adventitial VV could develop AAAs. We created a novel animal model of adventitial VV hypoperfusion with a combination of a polyurethane catheter insertion and a suture ligation of the infrarenal abdominal aorta in rats. VV hypoperfusion caused tissue hypoxia and developed infrarenal AAA, which had similar morphological and pathological characteristics to human AAA. In human AAA tissue, the adventitial VV were stenotic in both small AAAs (30-49 mm in diameter) and in large AAAs (> 50 mm in diameter), with the sac tissue in these AAAs being ischemic and hypoxic. These results indicate that hypoperfusion of adventitial VV has critical effects on the development of infrarenal AAA.",
author = "Hiroki Tanaka and Nobuhiro Zaima and Takeshi Sasaki and Masaki Sano and Naoto Yamamoto and Takaaki Saito and Kazunori Inuzuka and Takahiro Hayasaka and Naoko Goto-Inoue and Yuki Sugiura and Kohji Sato and Hirona Kugo and Tatsuya Moriyama and Hiroyuki Konno and Mitsutoshi Setou and Naoki Unno",
note = "Funding Information: We thank all the staff of the Second Department of Surgery of the Hamamatsu University School of Medicine who helped during our patients{\textquoteright} surgeries and postoperative care. We also thank the members of the SENTAN team for supporting the development of the high-resolution MALDI-IMS system, particularly the employees of Shimadzu Corporation. We are grateful to Y. Sugiyama and S. Kamei for their assistance. This work was supported by Grants-in-Aid for Scientific Research (B) (20291958) to N.U, (C) (26462103) to K.I.; Grants-in-Aid for Young Scientists (A) (25713024) to N.Z.; a Grant-in-Aid for SENTAN from the Japan Science and Technology Agency (JST); Tokutei Lipid Machinery; and Young Scientists S (2067004) to M.Se. Financial support for overseas study was provided by the Japan Research Foundation for Clinical Pharmacology to H.T. Publisher Copyright: {\textcopyright} 2015 Tanaka et al.",
year = "2015",
month = aug,
day = "26",
doi = "10.1371/journal.pone.0134386",
language = "English",
volume = "10",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",
}