Hypothermia for neonatal encephalopathy: Nationwide Survey of Clinical Practice in Japan as of August 2010

Osuke Iwata, Makoto Nabetani, Toshiki Takenouchi, Takayuki Iwaibara, Sachiko Iwata, Masanori Tamura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background: Therapeutic hypothermia is now recommended as a standard of care for neonatal encephalopathy. Although adherence to standard cooling protocols used in the phase-III trials is essential, empiric approaches have prevailed in Japan. Aim: To elucidate the gap between the standard cooling methods and the current practice in Japan. Method: In July 2010, a questionnaire regarding the practice of neonatal encephalopathy was mailed to clinical leads of registered neonatal intensive care units. Result: 56.2% of the units were incapable of offering therapeutic hypothermia because of the reasons such as the shortage of human/medical resources (85.1%) and limited number of cases (21.1%). Eighty-nine centres provided therapeutic hypothermia using either selective-head cooling (88.8%) or whole-body cooling (11.2%). Various target temperatures and cooling durations were used; 20.2% of the units cooled infants without using purpose-built equipments, whereas 14.6% did not continuously monitor the body temperature. Discussion: Only 43.8% of the units provided therapeutic hypothermia. Even in centres where hypothermia was offered, adherence to the standard protocols was extremely poor. To secure the safety and efficacy, further promotion of the standard cooling protocols is required; an efficient cooling centre network has to be established by optimizing the work forth distribution and transportation system.

Original languageEnglish
Pages (from-to)e197-e202
JournalActa Paediatrica, International Journal of Paediatrics
Issue number5
Publication statusPublished - 2012 May


  • Neonatal encephalopathy
  • Therapeutic hypothermia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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