ICOS costimulation in inflammatory bowel disease

Takanori Kanai, Teruji Totsuka, Katsunari Tezuka, Mamoru Watanabe

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


For years, medical researchers have striven to develop selective immunotherapies that could specifically ameliorate pathogenic immune responses without immunocompromising the patient. Blockade of many known receptors on T cells can inhibit the initiation of immune responses. However, this approach is problematic in that it is not possible to predict the onset of disease in patients. Current immunotherapies are unsatisfactory for the sporadic exacerbating type of diseases such as multiple sclerosis and inflammatory bowel disease (IBD), because they require either long-term treatment or acute treatment with high-dose immunosuppressants. With regard to this issue, the inducible and inflammatory site-specific molecule, inducible costimulator (ICOS), may be particularly useful as an ideal targeting molecule for the strategy of treatment of human IBD patients.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalJournal of gastroenterology
Issue numberSUPPL. 14
Publication statusPublished - 2002 Nov 1
Externally publishedYes


  • Crohn's disease
  • Murine
  • Th1

ASJC Scopus subject areas

  • Gastroenterology


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