TY - JOUR
T1 - Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis
AU - Yuri, Masatoshi
AU - Tokumoto, Marie
AU - Hara, Noriyuki
AU - Fujimoto, Yoshinori
AU - Kobayashi, Noriko
AU - Morisaki, Masuo
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Incubation of [27-13C]-3a,7a,12a-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by l3C-NMR analysis of the incubation product has resulted in the identification of [26-13C]-27-nor-3a,7a,12a-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3a,7a,12a-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.
AB - Incubation of [27-13C]-3a,7a,12a-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by l3C-NMR analysis of the incubation product has resulted in the identification of [26-13C]-27-nor-3a,7a,12a-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3a,7a,12a-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.
KW - 13C-label
KW - 27-nor-3α,7α,12α-trihydroxycoprostan-24-one
KW - cholic acid 3α,7α,12α-trihydroxycoprost-24-en-26-oic acid
KW - β-oxidation
UR - http://www.scopus.com/inward/record.url?scp=0027198106&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027198106&partnerID=8YFLogxK
U2 - 10.1248/cpb.41.1327
DO - 10.1248/cpb.41.1327
M3 - Article
C2 - 8375003
AN - SCOPUS:0027198106
SN - 0009-2363
VL - 41
SP - 1327
EP - 1329
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 7
ER -