Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Tetsuya Nishimura; Yuhki Nakatake; Morichika Konishi; Nobuyuki Itoh

doi:10.1016/S0167-4781(00)00067-1

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Tetsuya Nishimura, Yuhki Nakatake, Morichika Konishi, Nobuyuki Itoh

Research output: Contribution to journal › Article › peer-review

684 Citations (Scopus)

Abstract

We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus (~30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical (~75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar (~35% amino acid identity) to FGF-19. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	203-206
Number of pages	4
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1492
Issue number	1
DOIs	https://doi.org/10.1016/S0167-4781(00)00067-1
Publication status	Published - 2000 Jun 21
Externally published	Yes

Keywords

FGF-21
Fibroblast growth factor
Gene family
Liver
cDNA

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/S0167-4781(00)00067-1

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title = "Identification of a novel FGF, FGF-21, preferentially expressed in the liver",

abstract = "We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus (~30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical (~75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar (~35% amino acid identity) to FGF-19. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "FGF-21, Fibroblast growth factor, Gene family, Liver, cDNA",

author = "Tetsuya Nishimura and Yuhki Nakatake and Morichika Konishi and Nobuyuki Itoh",

note = "Funding Information: This work was supported in part by the Yamada Science Foundation, the Yamanouchi Foundation on Metabolic Disorders, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, and the Human Frontier Science Program, France.",

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doi = "10.1016/S0167-4781(00)00067-1",

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AU - Nishimura, Tetsuya

AU - Nakatake, Yuhki

AU - Konishi, Morichika

AU - Itoh, Nobuyuki

N1 - Funding Information: This work was supported in part by the Yamada Science Foundation, the Yamanouchi Foundation on Metabolic Disorders, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, and the Human Frontier Science Program, France.

PY - 2000/6/21

Y1 - 2000/6/21

N2 - We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus (~30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical (~75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar (~35% amino acid identity) to FGF-19. Copyright (C) 2000 Elsevier Science B.V.

AB - We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus (~30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical (~75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar (~35% amino acid identity) to FGF-19. Copyright (C) 2000 Elsevier Science B.V.

KW - FGF-21

KW - Fibroblast growth factor

KW - Gene family

KW - Liver

KW - cDNA

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Abstract

Keywords

ASJC Scopus subject areas

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