Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Tetsuya Nishimura, Yuhki Nakatake, Morichika Konishi, Nobuyuki Itoh

Research output: Contribution to journalArticlepeer-review

684 Citations (Scopus)


We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus (~30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical (~75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar (~35% amino acid identity) to FGF-19. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Issue number1
Publication statusPublished - 2000 Jun 21
Externally publishedYes


  • FGF-21
  • Fibroblast growth factor
  • Gene family
  • Liver
  • cDNA

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics


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