TY - JOUR
T1 - Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion
AU - Jin, Kai
AU - Imada, Toshihiro
AU - Hisamura, Ryuji
AU - Ito, Masataka
AU - Toriumi, Haruki
AU - Tanaka, Kenji F.
AU - Nakamura, Shigeru
AU - Tsubota, Kazuo
N1 - Funding Information:
Supported by Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research (KAKENHI) (grant 17K16983 to T.I.).
Publisher Copyright:
© 2020 American Society for Investigative Pathology
PY - 2020/5
Y1 - 2020/5
N2 - Tear fluid secreted from the exocrine lacrimal gland (LG) has an essential role in maintaining a homeostatic environment for a healthy ocular surface. Tear secretion is regulated by the sympathetic and parasympathetic components of the autonomic nervous system, although the contribution of each component is not fully understood. To investigate LG innervation, we identified sympathetic and parasympathetic postganglionic nerves, specifically innervating the mouse LG, by injecting a retrograde neuronal tracer into the LG. Interruption of neural stimuli to the LG by the denervation of these postganglionic nerves immediately and chronically decreased tear secretion, leading to LG atrophy along with destruction of the lobular structure. This investigation also found that parasympathetic, but not sympathetic, innervation was involved in these alterations.
AB - Tear fluid secreted from the exocrine lacrimal gland (LG) has an essential role in maintaining a homeostatic environment for a healthy ocular surface. Tear secretion is regulated by the sympathetic and parasympathetic components of the autonomic nervous system, although the contribution of each component is not fully understood. To investigate LG innervation, we identified sympathetic and parasympathetic postganglionic nerves, specifically innervating the mouse LG, by injecting a retrograde neuronal tracer into the LG. Interruption of neural stimuli to the LG by the denervation of these postganglionic nerves immediately and chronically decreased tear secretion, leading to LG atrophy along with destruction of the lobular structure. This investigation also found that parasympathetic, but not sympathetic, innervation was involved in these alterations.
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U2 - 10.1016/j.ajpath.2020.01.007
DO - 10.1016/j.ajpath.2020.01.007
M3 - Article
C2 - 32084368
AN - SCOPUS:85084094373
SN - 0002-9440
VL - 190
SP - 1068
EP - 1079
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 5
ER -