IL-6 and G-CSF production resulting from lung cancer in an HIV patient

Naoki Kawakami, Ho Namkoong, Katsunori Masaki, Yutaka Kurebayashi, Masayuki Shimoda, Hiroshi Kotani, Hiroshi Fujiwara, Naoki Hasegawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Increasing reports have noted an increased prevalence of lung cancer in human immunodeficiency virus (HIV)-positive patients with poor prognosis. A 51-year-old HIV-positive man was diagnosed with stage IV squamous cell lung cancer. He had high grade spike intermittent fever and persistent elevation of the white blood cell count as well as C-reactive protein (CRP) levels. Although we suspected opportunistic infections, we did not detect any infection. The autopsy showed positive immunostaining for Interleukin-6 (IL-6) in plasma cells of the stromal regions and G-CSF in tumor cells, which were considered responsible for his significant tumor fever, leukocytosis and high titers of CRP. This case report highlights the need to consider cytokine-producing tumor as a differential diagnosis of fever and high inflammatory status in HIV-positive cancer patients.

Original languageEnglish
Article numbere00693
Publication statusPublished - 2020


  • G-CSF
  • Human immunodeficiency virus (HIV)
  • IL-6
  • Lung cancer
  • Tumor fever

ASJC Scopus subject areas

  • Infectious Diseases


Dive into the research topics of 'IL-6 and G-CSF production resulting from lung cancer in an HIV patient'. Together they form a unique fingerprint.

Cite this