IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

Koji Taniguchi; Michael Karin

doi:10.1016/j.smim.2014.01.001

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

Koji Taniguchi, Michael Karin

Research output: Contribution to journal › Review article › peer-review

491 Citations (Scopus)

Abstract

Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.

Original language	English
Pages (from-to)	54-74
Number of pages	21
Journal	Seminars in Immunology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2014.01.001
Publication status	Published - 2014 Feb
Externally published	Yes

Keywords

Colorectal cancer
Gastric cancer
Gp130
Hepatocellular carcinoma
IL-11
IL-6
STAT3

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.smim.2014.01.001

Cite this

@article{cb32e0c414ea4e28a22d60427234f170,

title = "IL-6 and related cytokines as the critical lynchpins between inflammation and cancer",

abstract = "Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.",

keywords = "Colorectal cancer, Gastric cancer, Gp130, Hepatocellular carcinoma, IL-11, IL-6, STAT3",

author = "Koji Taniguchi and Michael Karin",

note = "Funding Information: We thank Dr. Sergei Grivennikov (Fox Chase Cancer Center) for his comments. This work was supported by the Postdoctoral Fellowship for Research Abroad , the Research Fellowship for Young Scientists and the Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation from the Japan Society for the Promotion of Science , the Uehara Memorial Foundation Fellowship , the Mochida Memorial Foundation for Medical and Pharmaceutical Research , and the Kanae Foundation for the Promotion of Medical Science to K.T.; and by the National Institutes of Health and the American Association for Cancer Research to M.K., who is an American Cancer Society Research Professor and holds the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases.",

year = "2014",

month = feb,

doi = "10.1016/j.smim.2014.01.001",

language = "English",

volume = "26",

pages = "54--74",

journal = "Seminars in Immunology",

issn = "1044-5323",

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number = "1",

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TY - JOUR

T1 - IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

AU - Taniguchi, Koji

AU - Karin, Michael

N1 - Funding Information: We thank Dr. Sergei Grivennikov (Fox Chase Cancer Center) for his comments. This work was supported by the Postdoctoral Fellowship for Research Abroad , the Research Fellowship for Young Scientists and the Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation from the Japan Society for the Promotion of Science , the Uehara Memorial Foundation Fellowship , the Mochida Memorial Foundation for Medical and Pharmaceutical Research , and the Kanae Foundation for the Promotion of Medical Science to K.T.; and by the National Institutes of Health and the American Association for Cancer Research to M.K., who is an American Cancer Society Research Professor and holds the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases.

PY - 2014/2

Y1 - 2014/2

N2 - Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.

AB - Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.

KW - Colorectal cancer

KW - Gastric cancer

KW - Gp130

KW - Hepatocellular carcinoma

KW - IL-11

KW - IL-6

KW - STAT3

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UR - http://www.scopus.com/inward/citedby.url?scp=84896494013&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2014.01.001

DO - 10.1016/j.smim.2014.01.001

M3 - Review article

C2 - 24552665

AN - SCOPUS:84896494013

SN - 1044-5323

VL - 26

SP - 54

EP - 74

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 1

ER -

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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