Imaging of tumor clones with differential liver colonization

Go Oshima, Sean C. Wightman, Abhineet Uppal, Melinda E. Stack, Sean P. Pitroda, Jonathan J. Oskvarek, Xiaona Huang, Mitchell C. Posner, Samuel Hellman, Ralph R. Weichselbaum, Nikolai N. Khodarev

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We present a model of hepatic colorectal metastases which represents monoclonal cell lines double-labeled by luciferase and tdTomato. These cells form liver metastasis in varying numbers and patterns similar to those observed in patients. Using in vivo and ex vivo luminescent and fluorescent imaging we determine the growth kinetics and clonogenic frequency of tumor cells colonizing liver. Molecular profiling detected stable expressional differences between clones consistent with their phenotypes. The data indicate that clinically relevant phenotypes of liver metastases can be modeled in vivo.

Original languageEnglish
Article number10946
JournalScientific reports
Publication statusPublished - 2015 Jun 22
Externally publishedYes

ASJC Scopus subject areas

  • General


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