Immune recognition and rejection of allogeneic skin grafts

Gilles Benichou, Yohei Yamada, Seok Hyun Yun, Charles Lin, Michael Fray, Georges Tocco

Research output: Contribution to journalReview articlepeer-review

112 Citations (Scopus)


The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate the recipient's draining lymph nodes where they present donor antigens via two mechanisms: the direct pathway, in which T cells recognize intact donor MHC antigens on donor DCs; and the indirect pathway, involving T-cell recognition of donor peptides bound to self-MHC molecules on recipient DCs. Some recent studies have suggested that T cells can become activated via recognition of donor MHC molecules transferred on recipient antigen-presenting cells (semidirect pathway). Activation of T cells via direct or indirect allorecognition is sufficient to trigger acute rejection of allogeneic skin grafts. In addition, allospecific antibodies contribute to the rejection process either by killing allogeneic targets in a complement-dependent fashion or by opsonizing donor cells and forming immune complexes. Finally, several studies demonstrate that NK cells, activated due to missing self-MHC class I molecules on allogeneic cells, are involved in allogeneic skin graft rejection via direct killing of donor cells and through the production of proinflammatory cytokines including IFN-γ and TNF-α.

Original languageEnglish
Pages (from-to)757-770
Number of pages14
Issue number6
Publication statusPublished - 2011 Jun
Externally publishedYes


  • B lymphocytes
  • NK cells
  • T lymphocytes
  • allorecognition
  • passenger leukocytes
  • skin transplantation
  • transplant rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology


Dive into the research topics of 'Immune recognition and rejection of allogeneic skin grafts'. Together they form a unique fingerprint.

Cite this