Immunodeficiency in patients with thymoma-associated myasthenia gravis

Kei Ishizuchi, Tsubasa Takizawa, Yuko Ohnuki, Koji Sekiguchi, Haruhiko Motegi, Munenori Oyama, Jin Nakahara, Takashi Shiina, Shigeaki Suzuki

Research output: Contribution to journalArticlepeer-review


Thymoma with immunodeficiency is sometimes accompanied by myasthenia gravis (MG), but the clinical characteristics have not been elucidated. This study aimed to characterize its clinical and immunological features. Of the 132 thymoma-associated MG patients, 9 patients presented with immunodeficiency. All suffered from severe pneumonia, and most had invasive thymoma and autoimmune disorders. DRB1*08:03 and DQB1*06:01 alleles were frequently detected. Compared to group without immunodeficiency, they showed no significant differences in the severity of MG, significantly lower IgG concentrations and higher mortality rate. Thymoma-associated MG with immunodeficiency is a distinct subset requiring special attention to prevent infection during the follow-up period.

Original languageEnglish
Article number577950
JournalJournal of Neuroimmunology
Publication statusPublished - 2022 Oct 15


  • Immunodeficiency
  • Immunoglobulin G
  • Infections
  • Myasthenia gravis
  • Thymoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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