Immunoglobulin G4-Related Disease Arising from the Bladder Wall

Ryohei Kufukihara, Naoya Niwa, Ryuichi Mizuno, Kentaro Ohara, Shuji Mikami, Eiji Kikuchi, Mototsugu Oya

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. This patient had a past history of autoimmune pancreatitis and presented with incidental bladder tumor. Magnetic resonance imaging showed low signal intensity tumor on T2-weighted image, and no invasion to the muscular layer. We performed transurethral resection. Pathological findings showed that there were chronic inflammatory changes infiltrates under the epithelium, and IgG4-positive plasma cells were scattered throughout the lesion. They met the pathological diagnostic criteria for IgG4-RD. We think this is the first case of IgG4-RD arising from and confined to the inside of the bladder wall.

Original languageEnglish
Pages (from-to)488-490
Number of pages3
JournalUrologia Internationalis
Issue number4
Publication statusPublished - 2019 Nov 1


  • Bladder tumor
  • Immunoglobulin G4-related disease

ASJC Scopus subject areas

  • Urology


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