Immunological adjuvant activity of pectinioside a, the steroidal saponin from the starfish Patiria pectinifera

Osamu Kawase; Osamu Ohno; Kiyotake Suenaga; Xuenan Xuan

doi:10.1177/1934578x1601100511

Immunological adjuvant activity of pectinioside a, the steroidal saponin from the starfish Patiria pectinifera

Osamu Kawase, Osamu Ohno, Kiyotake Suenaga, Xuenan Xuan

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The steroidal saponin, pectinioside A, was isolated from the starfish, Patiria pectinifera. When it was subcutaneously injected into mice with ovalbumin (OVA), it facilitated the production of OVA-specific total IgG and IgG1 but not IgG2a. To our knowledge, this is the first report suggesting that starfish saponin has the potential to be an immunological adjuvant, stimulating Th2 type immune response.

Original language	English
Pages (from-to)	605-606
Number of pages	2
Journal	Natural product communications
Volume	11
Issue number	5
DOIs	https://doi.org/10.1177/1934578x1601100511
Publication status	Published - 2016 May

Keywords

Immunologcal adjuvant
Patiria pectinifera
Pectinioside
Starfish
Steroidal saponin

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1601100511

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abstract = "The steroidal saponin, pectinioside A, was isolated from the starfish, Patiria pectinifera. When it was subcutaneously injected into mice with ovalbumin (OVA), it facilitated the production of OVA-specific total IgG and IgG1 but not IgG2a. To our knowledge, this is the first report suggesting that starfish saponin has the potential to be an immunological adjuvant, stimulating Th2 type immune response.",

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author = "Osamu Kawase and Osamu Ohno and Kiyotake Suenaga and Xuenan Xuan",

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AU - Ohno, Osamu

AU - Suenaga, Kiyotake

AU - Xuan, Xuenan

PY - 2016/5

Y1 - 2016/5

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AB - The steroidal saponin, pectinioside A, was isolated from the starfish, Patiria pectinifera. When it was subcutaneously injected into mice with ovalbumin (OVA), it facilitated the production of OVA-specific total IgG and IgG1 but not IgG2a. To our knowledge, this is the first report suggesting that starfish saponin has the potential to be an immunological adjuvant, stimulating Th2 type immune response.

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KW - Patiria pectinifera

KW - Pectinioside

KW - Starfish

KW - Steroidal saponin

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Immunological adjuvant activity of pectinioside a, the steroidal saponin from the starfish Patiria pectinifera

Abstract

Keywords

ASJC Scopus subject areas

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