TY - JOUR
T1 - Immunological Study of the Colonic Mucosal Cell Destruction in Ulcerative Colitis
T2 - Role of ADCC Mechanism
AU - Aiso, Sadakazu
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp. in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon's cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.
AB - Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp. in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon's cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.
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U2 - 10.11405/nisshoshi1964.78.2330
DO - 10.11405/nisshoshi1964.78.2330
M3 - Article
C2 - 7341793
AN - SCOPUS:0019758404
SN - 0446-6586
VL - 78
SP - 2330
EP - 2336
JO - Nippon Shokakibyo Gakkai Zasshi
JF - Nippon Shokakibyo Gakkai Zasshi
IS - 12
ER -
