Immunotherapeutic approach to the treatment and prevention of obesity

Tatsuhiko Azegami, Hiroshi Itoh

Research output: Chapter in Book/Report/Conference proceedingChapter


Clinical availability of anti-obesity drugs is limited, and their inadequate effectiveness and safety concerns sometimes discourage widespread use. A therapeutic vaccine has the potential to be an attractive tool for preventing and treating obesity, because of the possibility of prolonged therapeutic effect and low frequency of administration. Experimental investigations have shown that vaccines targeting endogenous molecules that promote obesity could be a viable alternative. Recent novelties in drug-delivery systems and biotechnology will support further progress in vaccine development. This chapter provides an overview of recent advances in the area.

Original languageEnglish
Title of host publicationObesity and Diabetes
Subtitle of host publicationScientific Advances and Best Practice
PublisherSpringer International Publishing
Number of pages6
ISBN (Electronic)9783030533700
ISBN (Print)9783030533694
Publication statusPublished - 2020 Dec 14


  • Adenovirus 36
  • Adipocyte
  • Ghrelin
  • Glucose-dependent Insulinotropic Polypeptide
  • Immunotherapy
  • Somatostatin
  • Vaccine

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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