[Immunotherapy targeting cancer stem cells].

Yutaka Kawakami, Maiko Matsushita, Ryo Ueda, Nobuo Tsukamoto, Shigeki Ohta

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Cancer stem cells are relatively resistant to chemotherapy, and cause relapse of cancer. Thus, various strategies to eliminate cancer stem cells have recently been exploited. One of them is immunotherapy. To develop the immunotherapy targeting cancer stem cells, tumor antigens expressed in cancer stem cells have been identified, and their use in the immunotherapy is expected. However, cancer stem cells may have an immunosuppressive ability. Therefore, blockade of the immunosuppressive mechanisms of cancer stem cells may also be required for development of effective immunotherapies against cancer stem cells.

Original languageEnglish
Pages (from-to)2142-2146
Number of pages5
JournalNihon rinsho. Japanese journal of clinical medicine
Issue number12
Publication statusPublished - 2012 Dec

ASJC Scopus subject areas

  • Medicine(all)


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