Impact of depression on health utility value in cancer patients

Daisuke Fujisawa, Hironobu Inoguchi, Haruki Shimoda, Kazuhiro Yoshiuchi, Shinichiro Inoue, Asao Ogawa, Toru Okuyama, Tatsuo Akechi, Masaru Mimura, Ken Shimizu, Yosuke Uchitomi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Objective The quality-adjusted life year, which is usually calculated from the health utility value, is now a standard measurement used in political decision-making in health. Although depression is the leading cause of decrement in health utility in general population, impact of comorbid depression among cancer patients has not been studied sufficiently. Therefore, this study aimed to measure the impact of depression on cancer patients' health utility score, according to the severity of depression. Methods Impact of depression severity (measured by the Patient Health Questionnaire) on health utility score (measured by the EuroQoL-5 scale) was evaluated in a sample of 328 Japanese cancer patients, controlling for performance status, symptom burden, and demographic variables. Results The patients with depression had significantly lower health utility value than those without depression (mean decrement = 0.14). Decrements in health utility of 0.13, 0.18, and 0.19 were observed for mild, moderate, and moderately severe to severe level of depression, respectively. The difference was significant between groups. Depression severity was a significant predictor for health utility (standardized coefficient beta = -0.25), which was comparable with physical symptom burden and performance status. Participants' age, gender, cancer stage, and comorbid illness were not significant. The model explained 37.9% of the variance. Conclusions Even mild level of depression caused clinically meaningful decrement in health utility value in cancer patients, which was comparable with decrements due to major physical complications of cancer. Influence of depression should be carefully investigated when interpreting the quality-adjusted life year among cancer patients.

Original languageEnglish
Pages (from-to)491-495
Number of pages5
Issue number5
Publication statusPublished - 2016 May 1


  • DALY
  • EQ-5D
  • QALY
  • cancer
  • depression
  • oncology

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Oncology
  • Psychiatry and Mental health


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