Impact of generic entry to off-patent branded medicines in Japanese pharmaceutical market

Daigo Fukumoto, Takeshi Suzuki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The Japanese pharmaceutical market is known for having a relatively low market penetration of generic medicines. However, the velocity of generic penetration varies among medicines. Looking at current sales and share of off-patent branded medicines and generic medicines in Japanese pharmaceutical market, our main aim is to identify the factors associated with sales reductions of off-patent medicines and price competition caused by generic entry in the Japanese pharmaceutical market. We showed as one result that an increase in the number of generic maker entries significantly increases both price competition and sales reductions of off-patent branded medicines. As a second factor of note, we found that being subject to "NHI Drug Price Premium for Promoting the Creation of New Drugs and the Elimination of Off-label Use" before generic entry is related to maintaining sales of off-patent branded medicines after generic entry. The importance of generic medicines is increasing in association with the hypertrophy of health care expenditures in Japan. Efficient polices and corporate strategies reflecting market principles are strongly needed. Detailed results of this study on what determines whether sales and prices of off-patent medicines significantly decrease after generic entry in the Japanese pharmaceutical market should be useful for this purpose.

Original languageEnglish
Pages (from-to)114-122
Number of pages9
JournalJournal of Generic Medicines
Issue number3
Publication statusPublished - 2017 Sept 1


  • authorized generic medicine
  • Generic entry
  • Japan
  • price divergence rate
  • sales reduction
  • Z2 price reduction

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Impact of generic entry to off-patent branded medicines in Japanese pharmaceutical market'. Together they form a unique fingerprint.

Cite this