Impact of neoadjuvant and adjuvant chemotherapy on invasive lobular carcinoma: A propensity score-matched analysis of SEER data

Rurina Watanuki; Tetsu Hayashida; Takamichi Yokoe; Yuko Kawai; Masayuki Kikuchi; Ayako Nakashoji; Aiko Nagayama; Tomoko Seki; Maiko Takahashi; Yuko Kitagawa

doi:10.1111/tbj.13884

Impact of neoadjuvant and adjuvant chemotherapy on invasive lobular carcinoma: A propensity score-matched analysis of SEER data

Rurina Watanuki, Tetsu Hayashida, Takamichi Yokoe, Yuko Kawai, Masayuki Kikuchi, Ayako Nakashoji, Aiko Nagayama, Tomoko Seki, Maiko Takahashi, Yuko Kitagawa

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Invasive lobular carcinoma (ILC) has a different treatment response from invasive ductal carcinoma (IDC). We assessed whether perioperative chemotherapy was associated with improved prognosis in patients with ILC. Retrospective data of women who underwent surgery for ILC were extracted from the SEER database. Subjects were divided into non-chemotherapy and chemotherapy groups. Overall, 10 537 patients were included, and 2107 patients were stratified into each group after propensity score matching. Perioperative chemotherapy significantly improved 10-year survival rates for ILC, particularly in patients with large tumor size and lymph node metastases. Perioperative chemotherapy is effective for ILC patients with proper selection.

Original language	English
Pages (from-to)	1765-1770
Number of pages	6
Journal	Breast Journal
Volume	26
Issue number	9
DOIs	https://doi.org/10.1111/tbj.13884
Publication status	Published - 2020 Sept 1

Keywords

SEER
adjuvant chemotherapy
breast cancer-specific survival
invasive lobular carcinoma

ASJC Scopus subject areas

Internal Medicine
Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tbj.13884

Cite this

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title = "Impact of neoadjuvant and adjuvant chemotherapy on invasive lobular carcinoma: A propensity score-matched analysis of SEER data",

abstract = "Invasive lobular carcinoma (ILC) has a different treatment response from invasive ductal carcinoma (IDC). We assessed whether perioperative chemotherapy was associated with improved prognosis in patients with ILC. Retrospective data of women who underwent surgery for ILC were extracted from the SEER database. Subjects were divided into non-chemotherapy and chemotherapy groups. Overall, 10 537 patients were included, and 2107 patients were stratified into each group after propensity score matching. Perioperative chemotherapy significantly improved 10-year survival rates for ILC, particularly in patients with large tumor size and lymph node metastases. Perioperative chemotherapy is effective for ILC patients with proper selection.",

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TY - JOUR

T1 - Impact of neoadjuvant and adjuvant chemotherapy on invasive lobular carcinoma

T2 - A propensity score-matched analysis of SEER data

AU - Watanuki, Rurina

AU - Hayashida, Tetsu

AU - Yokoe, Takamichi

AU - Kawai, Yuko

AU - Kikuchi, Masayuki

AU - Nakashoji, Ayako

AU - Nagayama, Aiko

AU - Seki, Tomoko

AU - Takahashi, Maiko

AU - Kitagawa, Yuko

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Invasive lobular carcinoma (ILC) has a different treatment response from invasive ductal carcinoma (IDC). We assessed whether perioperative chemotherapy was associated with improved prognosis in patients with ILC. Retrospective data of women who underwent surgery for ILC were extracted from the SEER database. Subjects were divided into non-chemotherapy and chemotherapy groups. Overall, 10 537 patients were included, and 2107 patients were stratified into each group after propensity score matching. Perioperative chemotherapy significantly improved 10-year survival rates for ILC, particularly in patients with large tumor size and lymph node metastases. Perioperative chemotherapy is effective for ILC patients with proper selection.

AB - Invasive lobular carcinoma (ILC) has a different treatment response from invasive ductal carcinoma (IDC). We assessed whether perioperative chemotherapy was associated with improved prognosis in patients with ILC. Retrospective data of women who underwent surgery for ILC were extracted from the SEER database. Subjects were divided into non-chemotherapy and chemotherapy groups. Overall, 10 537 patients were included, and 2107 patients were stratified into each group after propensity score matching. Perioperative chemotherapy significantly improved 10-year survival rates for ILC, particularly in patients with large tumor size and lymph node metastases. Perioperative chemotherapy is effective for ILC patients with proper selection.

KW - SEER

KW - adjuvant chemotherapy

KW - breast cancer-specific survival

KW - invasive lobular carcinoma

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JO - Breast Journal

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ER -

Impact of neoadjuvant and adjuvant chemotherapy on invasive lobular carcinoma: A propensity score-matched analysis of SEER data

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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