Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Stanley P.L. Leong; Markus Zuber; Robert L. Ferris; Yuko Kitagawa; Ramon Cabanas; Charles Levenback; Mark Faries; Sukamal Saha

doi:10.1002/jso.21815

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Stanley P.L. Leong, Markus Zuber, Robert L. Ferris, Yuko Kitagawa, Ramon Cabanas, Charles Levenback, Mark Faries, Sukamal Saha

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Abstract

The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

Original language	English
Pages (from-to)	518-530
Number of pages	13
Journal	Journal of Surgical Oncology
Volume	103
Issue number	6
DOIs	https://doi.org/10.1002/jso.21815
Publication status	Published - 2011 May 1

Keywords

outcomes
sentinel lymph nodes
tumor burden

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.21815

Cite this

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abstract = "The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.",

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AU - Zuber, Markus

AU - Ferris, Robert L.

AU - Kitagawa, Yuko

AU - Cabanas, Ramon

AU - Levenback, Charles

AU - Faries, Mark

AU - Saha, Sukamal

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AB - The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

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KW - tumor burden

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Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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