TY - JOUR
T1 - Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy
T2 - Propensity Score Matching Analysis
AU - Yatomi, Taisuke
AU - Uchida, Takahito
AU - Takamiya, Akihiro
AU - Wada, Masataka
AU - Kudo, Shun
AU - Nakajima, Kazuki
AU - Nishida, Hana
AU - Yamagata, Bun
AU - Mimura, Masaru
AU - Hirano, Jinichi
N1 - Funding Information:
This work was supported by the Japan Agency for Medical Research and Development (Grant Nos. JP21dm0307102h0003 and 22dm0307102h0004) and JSPS KAKENHI (Grant Nos. 17K10315 and 21K07551).
Publisher Copyright:
Copyright © 2022 Yatomi, Uchida, Takamiya, Wada, Kudo, Nakajima, Nishida, Yamagata, Mimura and Hirano.
PY - 2022/7/8
Y1 - 2022/7/8
N2 - Objective: Although anesthetics play an important role in electroconvulsive therapy (ECT), the clinical efficacy and seizure adequacy of sevoflurane in the course of ECT remain unclear. The purpose of this study was to examine the clinical efficacy and seizure adequacy of sevoflurane, compared with those of thiopental, in the course of ECT in patients with mood disorders. Methods: We conducted a retrospective chart review. Patients who underwent a course of ECT and received sevoflurane (n = 26) or thiopental (n = 26) were included. Factors associated with ECT and treatment outcomes were compared between the two groups using propensity score (PS) matching. Between-group differences were examined using an independent t-test for continuous variables and a χ2-test for categorical variables. Results: Patients who received sevoflurane needed more stimulations (sevoflurane: 13.2 ± 4 times, thiopental: 10.0 ± 2.5 times, df = 51, p = 0.001) and sessions (sevoflurane: 10.0 ± 2.1 times, thiopental: 8.4 ± 2.1 times, df = 51, p = 0.01) and had more inadequate seizures (sevoflurane: 5 ± 3.9 times, thiopental: 2.7 ± 2.7 times, df = 51, p = 0.015). Remission and response rates were similar in both groups. Conclusion: The present findings indicate that sevoflurane should be used with caution in ECT and only when the clinical rationale is clear.
AB - Objective: Although anesthetics play an important role in electroconvulsive therapy (ECT), the clinical efficacy and seizure adequacy of sevoflurane in the course of ECT remain unclear. The purpose of this study was to examine the clinical efficacy and seizure adequacy of sevoflurane, compared with those of thiopental, in the course of ECT in patients with mood disorders. Methods: We conducted a retrospective chart review. Patients who underwent a course of ECT and received sevoflurane (n = 26) or thiopental (n = 26) were included. Factors associated with ECT and treatment outcomes were compared between the two groups using propensity score (PS) matching. Between-group differences were examined using an independent t-test for continuous variables and a χ2-test for categorical variables. Results: Patients who received sevoflurane needed more stimulations (sevoflurane: 13.2 ± 4 times, thiopental: 10.0 ± 2.5 times, df = 51, p = 0.001) and sessions (sevoflurane: 10.0 ± 2.1 times, thiopental: 8.4 ± 2.1 times, df = 51, p = 0.01) and had more inadequate seizures (sevoflurane: 5 ± 3.9 times, thiopental: 2.7 ± 2.7 times, df = 51, p = 0.015). Remission and response rates were similar in both groups. Conclusion: The present findings indicate that sevoflurane should be used with caution in ECT and only when the clinical rationale is clear.
KW - anesthesia
KW - depression
KW - electroconvulsive therapy
KW - sevoflurane
KW - thiopental
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U2 - 10.3389/fnhum.2022.933622
DO - 10.3389/fnhum.2022.933622
M3 - Article
AN - SCOPUS:85134714574
SN - 1662-5161
VL - 16
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
M1 - 933622
ER -
