Improvement of brain function after surgery in infants with posterior quadrant cortical dysplasia

Riyo Ueda, Masaki Iwasaki, Yosuke Kita, Hiroshige Takeichi, Takashi Saito, Eiji Nakagawa, Kenji Sugai, Takashi Okada, Masayuki Sasaki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Objective: To reveal whether neurodevelopmental outcome of infants after epilepsy surgery can be quantitatively assessed by electroencephalography (EEG) functional connectivity analysis. Methods: We enrolled 13 infants with posterior quadrant dysplasia aged <2 years who were treated using posterior quadrantectomy and 21 age-matched infants. EEG was performed both before and one year after surgery. Developmental quotient (DQ) was assessed both before and 3 years after surgery. The phase lag index (PLI) of three different pairs of electrodes in the nonsurgical hemisphere, i.e., the anterior short distance (ASD), posterior short distance (PSD), and long distance (LD) pairs, were calculated as indices of brain connectivity. The relationship between the PLI and DQ was evaluated. Results: Overall, 77% infants experienced seizure freedom after surgery. The beta- and gamma- range PLI of PSD pairs increased preoperatively. All these pairs normalized postoperatively. Simple linear regression analysis revealed a significant relationship between the postoperative DQ and the postoperative beta-band PLI of ASD pairs. Conclusion: Preoperative abnormal hyper-connectivity was normalized to the control level after surgery. The postoperative hyperconnectivity was associated with long-term neurodevelopmental improvement. Significance: PLI quantifies neurodevelopmental improvements after posterior quadrantectomy.

Original languageEnglish
Pages (from-to)332-337
Number of pages6
JournalClinical Neurophysiology
Volume132
Issue number2
DOIs
Publication statusPublished - 2021 Feb
Externally publishedYes

Keywords

  • Cortical dysplasia
  • Development
  • Epilepsy
  • Infants
  • Posterior quadrantectomy

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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