In vitro translation-based computations

Yasubumi Sakakibara, Takahiro Hohsaka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The translation system in a cell is a powerful molecular machine conducted by ribosomes, tRNAs, and several translation factors to synthesize proteins. The translation process is very accurate according to the genetic code and directed from 5′-end to 3′-end on messenger RNA. We employ the translation mechanism combined with four-base codon techniques to develop a molecular machine which computes finite automata (finite-state machine). We report some experimental results where we have succeeded to implement a finite automaton on an E. coli in vitro translation system with four-base codons.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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