In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging

Robert V. Mulkern; Jiqun Meng; John L. Bowers; Koichi Oshio; Chun Zuo; Haicheng Li; Robert A. Kraft; Daniel S. Williamson; Diego Jaramillo

doi:10.1016/S0730-725X(97)00134-3

In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging

Robert V. Mulkern, Jiqun Meng, John L. Bowers, Koichi Oshio, Chun Zuo, Haicheng Li, Robert A. Kraft, Daniel S. Williamson, Diego Jaramillo

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging sequences have been used to extract lipid chemical composition indices in healthy adult bone marrow in the knee at 1.5 T. Since several spectroscopic echo readouts follow each excitation, the information acquired reflects a balance between spectral T₂ decay processes and spectral resolution. To examine this balance in detail, data sets with two different echo spacings and spectral resolutions have been acquired to compare the information available from each in studies of bone marrow. Oils for which high field (7 T) proton spectra were recorded were used to evaluate the accuracy of lipid chemical composition indices extracted from the line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging methods at 1.5 T. The extension of the method to fast spectroscopic imaging of bone marrow with multiple echoes is demonstrated.

Original language	English
Pages (from-to)	823-837
Number of pages	15
Journal	Magnetic Resonance Imaging
Volume	15
Issue number	7
DOIs	https://doi.org/10.1016/S0730-725X(97)00134-3
Publication status	Published - 1997
Externally published	Yes

Keywords

Bone marrow
CPMG
Lipids
RARE
Spectroscopic imaging

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/S0730-725X(97)00134-3

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title = "In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging",

abstract = "Line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging sequences have been used to extract lipid chemical composition indices in healthy adult bone marrow in the knee at 1.5 T. Since several spectroscopic echo readouts follow each excitation, the information acquired reflects a balance between spectral T2 decay processes and spectral resolution. To examine this balance in detail, data sets with two different echo spacings and spectral resolutions have been acquired to compare the information available from each in studies of bone marrow. Oils for which high field (7 T) proton spectra were recorded were used to evaluate the accuracy of lipid chemical composition indices extracted from the line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging methods at 1.5 T. The extension of the method to fast spectroscopic imaging of bone marrow with multiple echoes is demonstrated.",

keywords = "Bone marrow, CPMG, Lipids, RARE, Spectroscopic imaging",

author = "Mulkern, {Robert V.} and Jiqun Meng and Bowers, {John L.} and Koichi Oshio and Chun Zuo and Haicheng Li and Kraft, {Robert A.} and Williamson, {Daniel S.} and Diego Jaramillo",

note = "Funding Information: Acknowledgments-R.V.M. thanks the Whitaker Foundation for funds supporting this work. H.L. thanks the Howard Hughes Foundation for Fellowship Support.",

year = "1997",

doi = "10.1016/S0730-725X(97)00134-3",

language = "English",

volume = "15",

pages = "823--837",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

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T1 - In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging

AU - Mulkern, Robert V.

AU - Meng, Jiqun

AU - Bowers, John L.

AU - Oshio, Koichi

AU - Zuo, Chun

AU - Li, Haicheng

AU - Kraft, Robert A.

AU - Williamson, Daniel S.

AU - Jaramillo, Diego

N1 - Funding Information: Acknowledgments-R.V.M. thanks the Whitaker Foundation for funds supporting this work. H.L. thanks the Howard Hughes Foundation for Fellowship Support.

PY - 1997

Y1 - 1997

N2 - Line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging sequences have been used to extract lipid chemical composition indices in healthy adult bone marrow in the knee at 1.5 T. Since several spectroscopic echo readouts follow each excitation, the information acquired reflects a balance between spectral T2 decay processes and spectral resolution. To examine this balance in detail, data sets with two different echo spacings and spectral resolutions have been acquired to compare the information available from each in studies of bone marrow. Oils for which high field (7 T) proton spectra were recorded were used to evaluate the accuracy of lipid chemical composition indices extracted from the line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging methods at 1.5 T. The extension of the method to fast spectroscopic imaging of bone marrow with multiple echoes is demonstrated.

AB - Line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging sequences have been used to extract lipid chemical composition indices in healthy adult bone marrow in the knee at 1.5 T. Since several spectroscopic echo readouts follow each excitation, the information acquired reflects a balance between spectral T2 decay processes and spectral resolution. To examine this balance in detail, data sets with two different echo spacings and spectral resolutions have been acquired to compare the information available from each in studies of bone marrow. Oils for which high field (7 T) proton spectra were recorded were used to evaluate the accuracy of lipid chemical composition indices extracted from the line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging methods at 1.5 T. The extension of the method to fast spectroscopic imaging of bone marrow with multiple echoes is demonstrated.

KW - Bone marrow

KW - CPMG

KW - Lipids

KW - RARE

KW - Spectroscopic imaging

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DO - 10.1016/S0730-725X(97)00134-3

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AN - SCOPUS:0030923481

SN - 0730-725X

VL - 15

SP - 823

EP - 837

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 7

ER -

In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging

Abstract

Keywords

ASJC Scopus subject areas

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