In vivo visualization of subendocardial arteriolar response in renovascular hypertensive hearts

Toyotaka Yada, Masami Goto, Osamu Hiramatsu, Hiroyuki Tachibana, Eiji Toyota, Hiroshi Nakamoto, Yasuo Ogasawara, Hiroto Matsuda, Koki Arakawa, Koichi Hayashi, Hiromichi Suzuki, Fumihiko Kajiya

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Time-sequential responses to endothelium-dependent and -independent vasodilators and angiotensin-converting enzyme (ACE) inhibitors were studied in the subendocardial arterioles (Endo) of canine renovascular hypertension (HT) compared with subepicardial arterioles (Epi; both <120 μm) by charge-coupled device intravital microscope. Vascular responses to acetylcholine, papaverine, and cilazaprilat were compared between normotensive (NT) and HT dogs [4 wk and 12 wk of HT (4wHT and 12wHT)]. The acetylcholine-induced vasodilation of Endo in both 4wHT and 12wHT was smaller than that of NT (both P < 0.01 vs. 4wHT and 12wHT), and that of Epi was smaller than that of NT only in 12wHT (P < 0.05). The papaverine-induced vasodilation of Endo, but not Epi, was impaired only in 12wHT (both P < 0.01 vs. NT and 4wHT). Vasodilation by cilazaprilat remained unchanged at 4wHT and 12wHT in both Epi and Endo. In conclusion, at the early stage, the endothelium-dependent response of Endo was impaired, whereas at the later stage, the endothelium-dependent and -independent responses of Endo and the endothelium-dependent response of Epi were impaired. However, the vasodilatory responses to the ACE inhibitor were maintained in both Endo and Epi of HT.

Original languageEnglish
Pages (from-to)H1785-H1792
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number5 53-5
Publication statusPublished - 2003 May 1


  • Angiotensin-converting enzyme inhibitor
  • Endothelium-dependent and -independent vasodilators

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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