In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope

Naoki Hosoe, Taku Kobayashi, Takanori Kanai, Rieko Bessho, Tetsuro Takayama, Nagamu Inoue, Hiroyuki Imaeda, Yasushi Iwao, Seiki Kobayashi, Makio Mukai, Haruhiko Ogata, Toshifumi Hibi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: The endocytoscopy system (ECS) is a new method to provide real-time super-magnifying microscopic imaging in vivo. Routine diagnosis of amebic colitis requires multiple tests that are both time consuming and costly. Objective: To determine the feasibility of ECS to directly detect the amebic parasites in vivo. Design: Prospective, single-center, pilot study. Setting: Tertiary-care university hospital. Patients: This study involved 5 patients who were suspected to have amebic colitis by conventional colonoscopy in our institute. Interventions: A super-magnifying ECS with 450 × magnification. Main Outcome Measurements: We compared ECS findings with those of conventional methodsserum antibody tests and histology of colon biopsy specimens. Results: We successfully visualized the amebic trophozoites in all 5 cases. In contrast, 3 specimens had positive results on serology, and 3 had positive histology results on hematoxylin and eosin staining. Limitations: Pilot study with a limited number of patients. Findings were compared only with serology and histology findings. Conclusions: ECS would be a useful tool for the prompt diagnosis of amebic colitis via the real-time in vivo visualization of amebic trophozoites.

Original languageEnglish
Pages (from-to)643-646
Number of pages4
JournalGastrointestinal Endoscopy
Issue number3
Publication statusPublished - 2010 Sept

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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