Increased Body Temperature After Reperfused Acute Myocardial Infarction Is Associated With Adverse Left Ventricular Remodeling

Kotaro Naito, Toshihisa Anzai, Tsutomu Yoshikawa, Yuichiro Maekawa, Yasuo Sugano, Takashi Kohno, Keitaro Mahara, Teruo Okabe, Yasushi Asakura, Satoshi Ogawa

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15 Citations (Scopus)


Background: Fever is frequently observed in patients with acute myocardial infarction (AMI); however, its prognostic significance remains to be determined. We sought to determine the prognostic significance of increased body temperature (BT) after AMI. Methods and Results: We examined 156 consecutive patients with reperfused first anterior AMI. Axillary BT was serially measured every 6 hours for a week. Patients were divided into quartiles by peak BT from the lowest to highest levels. Peak BT within the first week showed a significant positive correlation with peak C-reactive protein level (P < .0001), but not with peak creatine kinase level. There were positive correlations of peak BT with the incidence of pump failure (P = .022), left ventricular (LV) aneurysm (P = .029), and readmission for heart failure (P = .006). Higher peak BT was associated with greater LV end-diastolic volume (P = .031), greater end-systolic volume (P = .008), and lower LV ejection fraction (P = .014) 2 weeks after AMI. Multiple logistic regression analyses revealed that peak BT quartile was an independent predictor of in-hospital cardiac events (odds ratio = 1.61/quartile, P = .008). Furthermore, peak BT quartile was a significant predictor of readmission for heart failure by Cox proportional hazard model analysis (P = .048). Conclusions: Increased BT after AMI was associated with a worse clinical outcome and infarct expansion, suggesting a relationship between systemic inflammatory response and LV remodeling.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalJournal of Cardiac Failure
Issue number1
Publication statusPublished - 2007 Feb 1


  • Acute coronary syndrome
  • Fever
  • Immune system
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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