Increased childhood BMI is associated with young adult serum uric acid levels: A linkage study from Japan

Erika Kuwahara; Yoshitaka Murakami; Tomonori Okamura; Hirokazu Komatsu; Akemi Nakazawa; Hideo Ushiku; Fumio Maejima; Yoshio Nishigaki; Yuji Nishiwaki

doi:10.1038/pr.2016.213

Increased childhood BMI is associated with young adult serum uric acid levels: A linkage study from Japan

Erika Kuwahara, Yoshitaka Murakami, Tomonori Okamura, Hirokazu Komatsu, Akemi Nakazawa, Hideo Ushiku, Fumio Maejima, Yoshio Nishigaki, Yuji Nishiwaki

Department of Preventive Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background:Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.Methods:We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6-12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.Results:The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.Conclusion:Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.

Original language	English
Pages (from-to)	293-298
Number of pages	6
Journal	Pediatric Research
Volume	81
Issue number	2
DOIs	https://doi.org/10.1038/pr.2016.213
Publication status	Published - 2017 Feb 1

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Increased childhood BMI is associated with young adult serum uric acid levels: A linkage study from Japan",

abstract = "Background:Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.Methods:We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6-12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.Results:The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.Conclusion:Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.",

author = "Erika Kuwahara and Yoshitaka Murakami and Tomonori Okamura and Hirokazu Komatsu and Akemi Nakazawa and Hideo Ushiku and Fumio Maejima and Yoshio Nishigaki and Yuji Nishiwaki",

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year = "2017",

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doi = "10.1038/pr.2016.213",

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T2 - A linkage study from Japan

AU - Kuwahara, Erika

AU - Murakami, Yoshitaka

AU - Okamura, Tomonori

AU - Komatsu, Hirokazu

AU - Nakazawa, Akemi

AU - Ushiku, Hideo

AU - Maejima, Fumio

AU - Nishigaki, Yoshio

AU - Nishiwaki, Yuji

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background:Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.Methods:We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6-12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.Results:The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.Conclusion:Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.

AB - Background:Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.Methods:We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6-12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.Results:The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.Conclusion:Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.

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Increased childhood BMI is associated with young adult serum uric acid levels: A linkage study from Japan

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