Increased expression of type VI collagen genes in drug-induced gingival enlargement

Hideo Shikata, Nobuo Utsumi, Takahiro Shimojima, Yoshio Oda, Yasunori Okada

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalFEBS Letters
Issue number1
Publication statusPublished - 1993 Nov 8
Externally publishedYes


  • Gene expression
  • Gingival overgrowth
  • Type VI collagen

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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