Indeterminate cell histiocytosis successfully treated with ultraviolet B phototherapy

M. Ishibashi, T. Ouchi, A. Tanikawa, A. Ishiko

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30 Citations (Scopus)


Indeterminate cell histiocytosis (ICH) is a rare disorder, characterized by infiltration of the skin by neoplastic cells that are characteristically positive for S-100 and CD1a, but lack Birbeck's granules. A 75-year-old man presented with a 4-year history of multiple papules on the trunk, limbs, face and neck. Skin biopsy revealed dense infiltration of histiocytic cells that were CD1a+/S100+, but lacked Birbeck's granules. No other abnormality was seen during a general examination including a computed tomography scan of the body, gallium scintigraphy, and an abdominal sonography. Broadband ultraviolet B (UVB) treatment was used for the skin lesions, and partial but almost complete remission was obtained. The case suggests that UVB phototherapy is an option for treatment of ICH.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalClinical and Experimental Dermatology
Issue number3
Publication statusPublished - 2008 May 1

ASJC Scopus subject areas

  • Dermatology


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