Indications for and use of long-acting injectable antipsychotics: Consideration from an inpatient setting

Taishiro Kishimoto, Sohag Sanghani, Mark J. Russ, Akeem N. Marsh, Joshua Morris, Suparna Basu, Majnu John, John M. Kane

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Studies have examined the differences in sociodemographic/clinical characteristics between patients on long-acting injectable (LAI) versus oral medications. However, most studies did not focus specifically on patients for whom LAIs would clearly be indicated. We performed a chart review of patients with schizophrenia or schizoaffective disorder. Patients were categorized as having an 'indication for an LAI' or not on the basis of their adherence history. Patients for whom an LAI was indicated and prescribed on discharge were then compared with similar patients for whom an LAI was not prescribed. Of 305 charts reviewed, consisting of 279 unique patients, 27.2% were judged to have an indication for an LAI (n=76), but only 32.9% of these (n=25) were discharged on an LAI. In the multiregression model, being African American, residing in a psychiatric residence, having a previous history of an LAI trial, and being treated with a higher antipsychotic dose were predictive of LAI prescription. It is important to focus on the population who are not likely to receive an LAI, but who have such indications for treatment.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalInternational clinical psychopharmacology
Issue number3
Publication statusPublished - 2017


  • antipsychotics
  • chart review
  • long-acting injectable
  • prescription
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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