Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

Yasunori Okada; Hiroyuki Tsuchiya; Hirokazu Shimizu; Katsuro Tomita; Isao Nakanishi; Hiroshi Sato; Motoharu Seiki; Kyoko Yamashita; Taro Hayakawa

doi:10.1016/0006-291X(90)91190-4

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

Yasunori Okada, Hiroyuki Tsuchiya, Hirokazu Shimizu, Katsuro Tomita, Isao Nakanishi, Hiroshi Sato, Motoharu Seiki, Kyoko Yamashita, Taro Hayakawa

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

Production of a 92-kDa gelatinase / type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor α (TNFα) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase / type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNFα may be important to allow cancer cells to be more invasive and metastatic.

Original language	English
Pages (from-to)	610-617
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	171
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(90)91190-4
Publication status	Published - 1990 Sept 14
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0006-291X(90)91190-4

Cite this

Okada, Y., Tsuchiya, H., Shimizu, H., Tomita, K., Nakanishi, I., Sato, H., Seiki, M., Yamashita, K., & Hayakawa, T. (1990). Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α. Biochemical and Biophysical Research Communications, 171(2), 610-617. https://doi.org/10.1016/0006-291X(90)91190-4

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α. / Okada, Yasunori; Tsuchiya, Hiroyuki; Shimizu, Hirokazu et al.
In: Biochemical and Biophysical Research Communications, Vol. 171, No. 2, 14.09.1990, p. 610-617.

Research output: Contribution to journal › Article › peer-review

Okada, Y, Tsuchiya, H, Shimizu, H, Tomita, K, Nakanishi, I, Sato, H, Seiki, M, Yamashita, K & Hayakawa, T 1990, 'Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α', Biochemical and Biophysical Research Communications, vol. 171, no. 2, pp. 610-617. https://doi.org/10.1016/0006-291X(90)91190-4

@article{75fc4a33a66f496a896d5478f2c56842,

title = "Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α",

abstract = "Production of a 92-kDa gelatinase / type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor α (TNFα) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase / type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNFα may be important to allow cancer cells to be more invasive and metastatic.",

author = "Yasunori Okada and Hiroyuki Tsuchiya and Hirokazu Shimizu and Katsuro Tomita and Isao Nakanishi and Hiroshi Sato and Motoharu Seiki and Kyoko Yamashita and Taro Hayakawa",

note = "Funding Information: ACKNOWLEDGMENTS to Dr. Edward D. Harris, Jr., of the Stanford University School of Medicine, U.S.A. for his critical reading of this study was supported part by Japan (support of Y.O.).",

year = "1990",

month = sep,

day = "14",

doi = "10.1016/0006-291X(90)91190-4",

language = "English",

volume = "171",

pages = "610--617",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

AU - Okada, Yasunori

AU - Tsuchiya, Hiroyuki

AU - Shimizu, Hirokazu

AU - Tomita, Katsuro

AU - Nakanishi, Isao

AU - Sato, Hiroshi

AU - Seiki, Motoharu

AU - Yamashita, Kyoko

AU - Hayakawa, Taro

N1 - Funding Information: ACKNOWLEDGMENTS to Dr. Edward D. Harris, Jr., of the Stanford University School of Medicine, U.S.A. for his critical reading of this study was supported part by Japan (support of Y.O.).

PY - 1990/9/14

Y1 - 1990/9/14

N2 - Production of a 92-kDa gelatinase / type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor α (TNFα) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase / type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNFα may be important to allow cancer cells to be more invasive and metastatic.

AB - Production of a 92-kDa gelatinase / type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor α (TNFα) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase / type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNFα may be important to allow cancer cells to be more invasive and metastatic.

UR - http://www.scopus.com/inward/record.url?scp=0025074287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025074287&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(90)91190-4

DO - 10.1016/0006-291X(90)91190-4

M3 - Article

C2 - 2169729

AN - SCOPUS:0025074287

SN - 0006-291X

VL - 171

SP - 610

EP - 617

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this