Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Tetsuya Kawata; Hisao Ito; Ken Motoori; Takuya Ueda; Naoyuki Shigematsu; Yoshiya Furusawa; Marco Durante; Kerry George; Honglu Wu; Francis A. Cucinotta

doi:10.1269/jrr.43.s169

Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Tetsuya Kawata, Hisao Ito, Ken Motoori, Takuya Ueda, Naoyuki Shigematsu, Yoshiya Furusawa, Marco Durante, Kerry George, Honglu Wu, Francis A. Cucinotta

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

Original language	English
Pages (from-to)	S169-173
Journal	Journal of radiation research
Volume	43 Suppl
DOIs	https://doi.org/10.1269/jrr.43.s169
Publication status	Published - 2002 Dec
Externally published	Yes

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging
Health, Toxicology and Mutagenesis

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10.1269/jrr.43.s169

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title = "Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.",

abstract = "The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.",

author = "Tetsuya Kawata and Hisao Ito and Ken Motoori and Takuya Ueda and Naoyuki Shigematsu and Yoshiya Furusawa and Marco Durante and Kerry George and Honglu Wu and Cucinotta, {Francis A.}",

year = "2002",

month = dec,

doi = "10.1269/jrr.43.s169",

language = "English",

volume = "43 Suppl",

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journal = "Journal of radiation research",

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T1 - Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

AU - Kawata, Tetsuya

AU - Ito, Hisao

AU - Motoori, Ken

AU - Ueda, Takuya

AU - Shigematsu, Naoyuki

AU - Furusawa, Yoshiya

AU - Durante, Marco

AU - George, Kerry

AU - Wu, Honglu

AU - Cucinotta, Francis A.

PY - 2002/12

Y1 - 2002/12

N2 - The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

AB - The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

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JF - Journal of radiation research

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Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Abstract

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