Induction of differentiation of human leukemia cells

M. Kizaki, H. Nakajima, Y. Ikeda

Research output: Contribution to journalReview articlepeer-review


Human myeloid leukemia cells do not differentiate into functional end-cells but remain in the proliferation pool. Human cell lines can serve as model for hematopoietic cells arrested at different stages of myeloid differentiation and helps to dissect the cellular and molecular events involved in leukemogenesis. Furthermore, several agents have been identified as inducers of differentiation of leukemia cells. Exciting new clinical observation have shown that patients with APL respond well to the treatment with all-trans retinoic acid. RAR-alpha gene was proved to translocated from chromosome 17 to a locus PML on chromosome 15. This new chimeric gene, PML-RAR alpha is extremely important to understand the leukemogenesis of APL.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalHuman cell : official journal of Human Cell Research Society
Issue number2
Publication statusPublished - 1992 Jun

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research


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