Inflammatory myopathies and human leukocyte antigen

Yuko Ohnuki, Shigeaki Suzuki, Takashi Shiina

Research output: Contribution to journalReview articlepeer-review


Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of subacute, chronic or acute systemic immune-mediated diseases of the skeletal muscles. Recently, research has shown the utility of adding new classifications of myopathies, mainly based on their pathology and the presence of specific autoantibodies. In addition, developments in genetics have helped reveal the genetic background of IIM. The human leukocyte antigen genomic region has been consistently shown to be the strongest genetic risk factor for IIM. The present review summarizes the previous and current literature on human leukocyte antigen analysis of IIM, as well as future directions for research.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalClinical and Experimental Neuroimmunology
Issue number4
Publication statusPublished - 2017 Nov


  • human leukocyte antigen
  • idiopathic inflammatory myopathy
  • myositis-specific autoantibodies

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology
  • Immunology and Microbiology (miscellaneous)
  • Clinical Neurology


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