Influence of alcohol abuse on recurrence after curative resection of hepatocellular carcinoma

S. Okada, H. Ishii, H. Nose, M. Yoshimori, K. Shimada, J. Yamamoto, T. Takayama, T. Kosuge, S. Yamasaki, M. Sakamoto, S. Hirohashi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background/Aim: We studied the influence of alcohol abuse (ethanol intake > 80 gm/day for > 5 yr.) on recurrence in 81 patients with hepatocellular carcinoma who had undergone curative hepatic resection. Twenty-nine patients were positive for alcohol abuse [AA(+)] and 52 were not [AA(-)]. Results: Recurrence of carcinoma within 2 and 27 postoperative months was observed in 45 (55.6%) of the 81 patients. The median disease-recurrence time was 12.0 mo in the AA(+) group and 24.1 mo in the AA(-) group (p < 0.01). The patterns of recurrence were classified into the following 4 types: single-nodular type (intrahepatic single nodule); multi-nodular type (intrahepatic multiple nodules); whole Liver type (diffuse recurrence over the whole remnant liver); and extrahepatic type (extrahepatic recurrence alone). Five (29.4%) of the 17 patients with recurrence in the AA(+) group demonstrated the whole liver type, compared with only 2 (7.1%) of the 28 patients in the AA(-) group (p < 0.05). Conclusion: Patients with alcohol abuse should be followed up particularly closely, even if they have received curative surgery, since alcohol abuse is strongly related to postoperative recurrence.

Original languageEnglish
Pages (from-to)944-949
Number of pages6
Issue number6
Publication statusPublished - 1995
Externally publishedYes


  • Alcohol abuse
  • Hepatectomy
  • Hepatocellular carcinoma
  • Postoperative recurrence

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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