Influence of indomethacin eyedrops on corneal epithelium after cataract surgery

M. Yamada, K. Tsubota, T. Nagamoto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We assessed the influence of indomethacin oily eyedrops on the corneal epithelium following cataract surgery. We used specular microscopy to observe the epithelium in the central cornea. The eyes were divided into 3 groups. In the indomethacin group of 10 eyes, indomethacin eyedrops were instilled before and during 1 month after surgery. In the oil group of 5 eyes, castor oil eyedrops without indomethacin was instilled. The findings were compared with those in the control group of 10 eyes. The state of corneal epithelium was documented with specular microscopic photography prior to surgery, and 1 week, 1 month and 3 months after surgery. The mean cell area in indomethacin group was significantly larger than that in control group at 1 week and 1 month after surgery (p < 0.001). The corneal epithelial score in indomethacin group was also higher than that in control at 1 week and 1 month after surgery (p < 0.05). There were no significant differences between the oil and control group. The findings indicate that indomethacin as oily eyedrops may induce damage in the corneal epithelium. This effect is ascribed to indomethacin and not to castor oil.

Original languageEnglish
Pages (from-to)455-459
Number of pages5
JournalJapanese Journal of Clinical Ophthalmology
Issue number4
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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