Influence of norfloxacin on blood coagulation in children

Keisuke Sunakawa; Takao Yokota; Hironobu Akita; Satoshi Iwata; Yoshitake Sato

doi:10.11250/chemotherapy1953.38.26

Influence of norfloxacin on blood coagulation in children

Keisuke Sunakawa, Takao Yokota, Hironobu Akita, Satoshi Iwata, Yoshitake Sato

Research output: Contribution to journal › Article › peer-review

Abstract

There have been reports of hemorrhagic manifestations associated with the administration of antibiotics, mainly beta-lactams recently introduced into the market. During the course of a clinical study to assess the safety of a new quinolone, norfloxacin (NFLX) in children, we investigated the drug's influence on blood coagulation and platelet functions. ADP-induced platelet aggregation was measured in seven pediatric patients from 6 months ‘to 10 years’ old being treated with NFLX. The mean values were 51.0±13.1% before administration and 63.8±17.2% during the treatment, showing an improvement in platelet function differing from cases commonly treated with other oral antibacterials. In parallel, tests on blood coagulation and PIVKA II were performed, and no abnormalities caused by NFLX were observed. Our results suggest that NFLX in children has less adverse effect on the normal function of hemostasis and blood coagulation.

Original language	English
Pages (from-to)	26-30
Number of pages	5
Journal	Chemotherapy
Volume	38
Issue number	1
DOIs	https://doi.org/10.11250/chemotherapy1953.38.26
Publication status	Published - 1990
Externally published	Yes

Keywords

Norfloxacin

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11250/chemotherapy1953.38.26

Cite this

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title = "Influence of norfloxacin on blood coagulation in children",

abstract = "There have been reports of hemorrhagic manifestations associated with the administration of antibiotics, mainly beta-lactams recently introduced into the market. During the course of a clinical study to assess the safety of a new quinolone, norfloxacin (NFLX) in children, we investigated the drug's influence on blood coagulation and platelet functions. ADP-induced platelet aggregation was measured in seven pediatric patients from 6 months {\textquoteleft}to 10 years{\textquoteright} old being treated with NFLX. The mean values were 51.0±13.1% before administration and 63.8±17.2% during the treatment, showing an improvement in platelet function differing from cases commonly treated with other oral antibacterials. In parallel, tests on blood coagulation and PIVKA II were performed, and no abnormalities caused by NFLX were observed. Our results suggest that NFLX in children has less adverse effect on the normal function of hemostasis and blood coagulation.",

keywords = "Norfloxacin",

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T1 - Influence of norfloxacin on blood coagulation in children

AU - Sunakawa, Keisuke

AU - Yokota, Takao

AU - Akita, Hironobu

AU - Iwata, Satoshi

AU - Sato, Yoshitake

PY - 1990

Y1 - 1990

N2 - There have been reports of hemorrhagic manifestations associated with the administration of antibiotics, mainly beta-lactams recently introduced into the market. During the course of a clinical study to assess the safety of a new quinolone, norfloxacin (NFLX) in children, we investigated the drug's influence on blood coagulation and platelet functions. ADP-induced platelet aggregation was measured in seven pediatric patients from 6 months ‘to 10 years’ old being treated with NFLX. The mean values were 51.0±13.1% before administration and 63.8±17.2% during the treatment, showing an improvement in platelet function differing from cases commonly treated with other oral antibacterials. In parallel, tests on blood coagulation and PIVKA II were performed, and no abnormalities caused by NFLX were observed. Our results suggest that NFLX in children has less adverse effect on the normal function of hemostasis and blood coagulation.

AB - There have been reports of hemorrhagic manifestations associated with the administration of antibiotics, mainly beta-lactams recently introduced into the market. During the course of a clinical study to assess the safety of a new quinolone, norfloxacin (NFLX) in children, we investigated the drug's influence on blood coagulation and platelet functions. ADP-induced platelet aggregation was measured in seven pediatric patients from 6 months ‘to 10 years’ old being treated with NFLX. The mean values were 51.0±13.1% before administration and 63.8±17.2% during the treatment, showing an improvement in platelet function differing from cases commonly treated with other oral antibacterials. In parallel, tests on blood coagulation and PIVKA II were performed, and no abnormalities caused by NFLX were observed. Our results suggest that NFLX in children has less adverse effect on the normal function of hemostasis and blood coagulation.

KW - Norfloxacin

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Influence of norfloxacin on blood coagulation in children

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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