TY - JOUR
T1 - Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema
AU - Yanagawa, Bobby
AU - Kataoka, Masaharu
AU - Ohnishi, Shunsuke
AU - Kodama, Makoto
AU - Tanaka, Koichi
AU - Miyahara, Yoshinori
AU - Ishibashi-Ueda, Hatsue
AU - Aizawa, Yoshifusa
AU - Kangawa, Kenji
AU - Nagaya, Noritoshi
N1 - Funding Information:
This work was supported by research grants for Cardiovascular Disease (16C-6 and 17A-1) and Comprehensive Research on Aging and Health from the Ministry of Health, Labour and Welfare, the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO); and Health and Labor Sciences Research Grants (Human Genome Tissue Engineering 009).
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Objective: Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model. Methods: One week after myosin injection, rats received a continuous infusion of AM or vehicle for 2 weeks, and pathological and physiological investigations were performed. Results: AM treatment significantly reduced the infiltration of inflammatory cells in myocarditic hearts, and decreased the expressions of macrophage chemoattractant protein-1, matrix metalloproteinase-2 and transforming growth factor-β. Myocardial edema indicated by increased heart weight to body weight ratio and wall thickness was attenuated by AM infusion (5.7 ± 0.5 vs. 6.5 ± 0.4 g/kg, and 1.9 ± 0.3 vs. 2.8 ± 0.5 mm, respectively). Infusion of AM significantly improved left ventricular maximum dP/dt and fractional shortening of myocarditic hearts (4203 ± 640 vs. 3450 ± 607 mm Hg/s, and 21.3 ± 4.1 vs. 14.7 ± 5.1%, respectively). Conclusion: Infusion of AM improved cardiac function and pathological findings in a rat model of acute myocarditis. Thus, infusion of AM may be a potent therapeutic strategy for acute myocarditis.
AB - Objective: Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model. Methods: One week after myosin injection, rats received a continuous infusion of AM or vehicle for 2 weeks, and pathological and physiological investigations were performed. Results: AM treatment significantly reduced the infiltration of inflammatory cells in myocarditic hearts, and decreased the expressions of macrophage chemoattractant protein-1, matrix metalloproteinase-2 and transforming growth factor-β. Myocardial edema indicated by increased heart weight to body weight ratio and wall thickness was attenuated by AM infusion (5.7 ± 0.5 vs. 6.5 ± 0.4 g/kg, and 1.9 ± 0.3 vs. 2.8 ± 0.5 mm, respectively). Infusion of AM significantly improved left ventricular maximum dP/dt and fractional shortening of myocarditic hearts (4203 ± 640 vs. 3450 ± 607 mm Hg/s, and 21.3 ± 4.1 vs. 14.7 ± 5.1%, respectively). Conclusion: Infusion of AM improved cardiac function and pathological findings in a rat model of acute myocarditis. Thus, infusion of AM may be a potent therapeutic strategy for acute myocarditis.
KW - Adrenomedullin
KW - Angiogenesis
KW - Autoimmune myocarditis
KW - Inflammation
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U2 - 10.1016/j.cardiores.2007.05.027
DO - 10.1016/j.cardiores.2007.05.027
M3 - Article
C2 - 17599815
AN - SCOPUS:34548407416
SN - 0008-6363
VL - 76
SP - 110
EP - 118
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 1
ER -