Inhibition of amyloid β aggregation and cytotoxicity by photodegradation using a designed fullerene derivative

Yasunori Ishida; Tomohiko Fujii; Kotaro Oka; Daisuke Takahashi; Kazunobu Toshima

doi:10.1002/asia.201100421

Inhibition of amyloid β aggregation and cytotoxicity by photodegradation using a designed fullerene derivative

Yasunori Ishida, Tomohiko Fujii, Kotaro Oka, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Photos allowed: Upon photoirradiation, a purpose-designed fullerene derivative effectively inhibited the cytotoxicity of Aβ₄₂ peptide in neuron-like PC12 cells by degrading the Aβ₄₂ monomer and oligomers, which are key compounds in Alzheimer's disease.

Original language	English
Pages (from-to)	2312-2315
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	6
Issue number	9
DOIs	https://doi.org/10.1002/asia.201100421
Publication status	Published - 2011 Sept 5

Keywords

Alzheimer's disease
amyloid beta-peptides
fullerenes
neuron-like cells
photochemistry

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1002/asia.201100421

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title = "Inhibition of amyloid β aggregation and cytotoxicity by photodegradation using a designed fullerene derivative",

abstract = "Photos allowed: Upon photoirradiation, a purpose-designed fullerene derivative effectively inhibited the cytotoxicity of Aβ42 peptide in neuron-like PC12 cells by degrading the Aβ42 monomer and oligomers, which are key compounds in Alzheimer's disease.",

keywords = "Alzheimer's disease, amyloid beta-peptides, fullerenes, neuron-like cells, photochemistry",

author = "Yasunori Ishida and Tomohiko Fujii and Kotaro Oka and Daisuke Takahashi and Kazunobu Toshima",

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AU - Toshima, Kazunobu

PY - 2011/9/5

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KW - neuron-like cells

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Inhibition of amyloid β aggregation and cytotoxicity by photodegradation using a designed fullerene derivative

Abstract

Keywords

ASJC Scopus subject areas

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