Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin

Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Shogo Kurasawa, Hiroshi Naganawa, Tomio Takeuchi, Z. Bao-quan, Kazuo Umezawa

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Psi-tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor-induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 μg/ml; thus, its inhibitory activity was 6-times stronger than that of genistein or orobol. When added to cultured A431 cells psi-tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi-tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalFEBS Letters
Issue number1-2
Publication statusPublished - 1988 Mar 28
Externally publishedYes


  • (Actinomycete)
  • Phosphatidylinositol turnover
  • Psi-tectorigenin
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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