Inhibition of enteropeptidase by antitrypsin drugs

Masashi Matsushima, Naohisa Yahagi, Masao Ichinose, Kazumasa Miki, Masao Omata, Hideshi Inoue, Takayuki Takahashi, Kenji Takahashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalBiomedical Research
Issue number5
Publication statusPublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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